Drug resistance of cancer cells is often correlated to an impaired activation of Programmed Cell Death (PCD), mainly occurring through the apoptotic pathway(s) accordingly, it has been assumed for a long time that the re-activation of apoptosis could be sufficient to promote the eradication of cancer cells. For decades, the scientific community has been working to understand not only the molecular mechanisms at the basis of the uncontrolled proliferation of cancer cells, but also how these cells become insensitive to internal/external stimuli promoting cell death. During tumor development, cancer cells can acquire many features such as sustained proliferative signaling (active oncogenes), evasion of growth suppressor functions, invasion of healthy tissues due to metastatic potential, replicative immortality, angiogenesis stimulation and resistance to cell death induced by chemotherapeutic agents. Cancer is one of the multifactorial and multistep complex disorders that accounts for a major cause of death all over the world, accounting 7.6 million deaths (around 13% of all deaths) in 2008 it is characterized by uncontrolled proliferation of abnormal cells that ends with the formation of a tumor.
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